5,094 research outputs found
Propagation of Errors for Matrix Inversion
A formula is given for the propagation of errors during matrix inversion. An
explicit calculation for a 2 by 2 matrix using both the formula and a Monte
Carlo calculation are compared. A prescription is given to determine when a
matrix with uncertain elements is sufficiently nonsingular for the calculation
of the covariances of the inverted matrix elements to be reliable.Comment: 18 pages, 4 figures, figure 4 contains two eps file
HTC Scientific Computing in a Distributed Cloud Environment
This paper describes the use of a distributed cloud computing system for
high-throughput computing (HTC) scientific applications. The distributed cloud
computing system is composed of a number of separate
Infrastructure-as-a-Service (IaaS) clouds that are utilized in a unified
infrastructure. The distributed cloud has been in production-quality operation
for two years with approximately 500,000 completed jobs where a typical
workload has 500 simultaneous embarrassingly-parallel jobs that run for
approximately 12 hours. We review the design and implementation of the system
which is based on pre-existing components and a number of custom components. We
discuss the operation of the system, and describe our plans for the expansion
to more sites and increased computing capacity
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density
Rationale:
In ventricular myocytes of large mammals, not all ryanodine receptor (RyR) clusters are associated with T-tubules (TTs); this fraction increases with cellular remodeling after myocardial infarction (MI).
Objective:
To characterize RyR functional properties in relation to TT proximity, at baseline and after MI.
Methods:
Myocytes were isolated from left ventricle of healthy pigs (CTRL) or from the area adjacent to a myocardial infarction (MI). Ca2+ transients were measured under whole-cell voltage clamp during confocal linescan imaging (fluo-3) and segmented according to proximity of TTs (sites of early Ca2+ release, F>F50 within 20 ms) or their absence (delayed areas). Spontaneous Ca2+ release events during diastole, Ca2+ sparks, reflecting RyR activity and properties, were subsequently assigned to either category.
Results:
In CTRL, spark frequency was higher in proximity of TTs, but spark duration was significantly shorter. Block of Na+/Ca2+ exchanger (NCX) prolonged spark duration selectively near TTs, while block of Ca2+ influx via Ca2+ channels did not affect sparks properties. In MI, total spark mass was increased in line with higher SR Ca2+ content. Extremely long sparks (>47.6 ms) occurred more frequently. The fraction of near-TT sparks was reduced; frequency increased mainly in delayed sites. Increased duration was seen in near-TT sparks only; Ca2+ removal by NCX at the membrane was significantly lower in MI.
Conclusion:
TT proximity modulates RyR cluster properties resulting in intracellular heterogeneity of diastolic spark activity. Remodeling in the area adjacent to MI differentially affects these RyR subpopulations. Reduction of the number of sparks near TTs and reduced local NCX removal limit cellular Ca2+ loss and raise SR Ca2+ content, but may promote Ca2+ waves
Analyzing Power Measurements for the Excitation of States in 28-Si and 24-Mg by Inelastic Scattering of Polarized Protons
Supported by the National Science Foundation and Indiana Universit
S-matrix approach to two-pion production in e^+e^- annihilation and tau decay
Based on the S-matrix approach, we introduce a modified formula for the
electromagnetic form factor which describes very well the
experimental data in the energy region GeV.
Using the CVC hypothesis we predict B(\tpp) = (24.75 \pm 0.38)\% , in
excellent agreement with recent experiments.Comment: Latex, 10 pages, submitted to Phys. Rev.
Measurements of Flavour Dependent Fragmentation Functions in Z^0 -> qq(bar) Events
Fragmentation functions for charged particles in Z -> qq(bar) events have
been measured for bottom (b), charm (c) and light (uds) quarks as well as for
all flavours together. The results are based on data recorded between 1990 and
1995 using the OPAL detector at LEP. Event samples with different flavour
compositions were formed using reconstructed D* mesons and secondary vertices.
The \xi_p = ln(1/x_E) distributions and the position of their maxima \xi_max
are also presented separately for uds, c and b quark events. The fragmentation
function for b quarks is significantly softer than for uds quarks.Comment: 29 pages, LaTeX, 5 eps figures (and colour figs) included, submitted
to Eur. Phys. J.
Determination of alpha_s using Jet Rates at LEP with the OPAL detector
Hadronic events produced in e+e- collisions by the LEP collider and recorded
by the OPAL detector were used to form distributions based on the number of
reconstructed jets. The data were collected between 1995 and 2000 and
correspond to energies of 91 GeV, 130-136 GeV and 161-209 GeV. The jet rates
were determined using four different jet-finding algorithms (Cone, JADE, Durham
and Cambridge). The differential two-jet rate and the average jet rate with the
Durham and Cambridge algorithms were used to measure alpha(s) in the LEP energy
range by fitting an expression in which order alpah_2s calculations were
matched to a NLLA prediction and fitted to the data. Combining the measurements
at different centre-of-mass energies, the value of alpha_s (Mz) was determined
to be
alpha(s)(Mz)=0.1177+-0.0006(stat.)+-0.0012$(expt.)+-0.0010(had.)+-0.0032(theo.)
\.Comment: 40 pages, 17 figures, Submitted to Euro. Phys. J.
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